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Co-administration of GLP-1 and glucagon As mentioned, enhancements in energy expenditure and reductions in food intake position glucagon pharmacology as a potentially valuable treatment for metabolic syndrome, however its hyperglycemic liability has made practical implementation non-existent [102], [161], [3], [30], [85]

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Nevertheless, the broad array of study designs, patient populations, and procedural settings provide a sufficiently comprehensive foundation to inform the clinical algorithm proposed in subsequent sections of this manuscript